Escherichia coli - enterotoxin

      Enterotoxin: enterotoxigenic Escherichia coli exotoxin released in the process of growth and reproduction, is divided into two kinds of heat-resistant and heat-labile. Heat-labile enterotoxin (Heatlabileenterotoxin, LT): the heat-labile, 65 ° C for 30 minutes inactivated. Of protein, and the large molecular weight and immunogenicity. By A, B subunit composition A is divided into A1 and A2, wherein A1 is the active portion of the toxin. B subunit and small intestinal epithelial cell surface GM1 ganglioside receptor binding, the A subunit across the cell membrane adenylate cyclase role of intracellular ATP into cAMP. When cAMP increased the lead to excessive secretion of small intestine liquid exceeds the absorptive capacity of the intestinal diarrhea. The LT's immunogenicity Vibrio cholerae enterotoxin Similar to the cross of both antisera and role.