HuHCA its congeners found

    1984 Tanaka et _1 J obtained after the immunization of chicken embryonic spinal cord membrane a monoclonal antibody, using this monoclonal antibody screening spine dry found, which corresponds to the unique antigen expression in motor neurons and backplane cell surface. So named it the SC1 (spinal o. Rd) antigen. It first early stage in motor neuron development, and continued until the embryo 7 days motor axons arrive dominated by muscle and begin to form synapses the .1990 Pourouie of _2-hybridoma technique identified a selective expressed in the chicken nervous system with the epithelial cell surface glycoprotein, called BEN. This substance expression in the axon extension in the nervous system plays an important role. The following year, Bums, etc. Similarly by the monoclonal antibody method, identifying fork a chicken cell surface protein, DM-GRASPo for further study of these three substances, three substances were cloned eDNA sequence and analysis of protein structure The results show: the eDNA sequence substantially the same molecular structure, and similar in the way of expression, and thus proved to be the same substance, i.e. BEN / SCI / the DM-the GRASP. Two study groups in the United States in 1992 and 1994, reported the congeners with a similar BEN/SC1/DM-GRASP the mouse, respectively called F84.1 glycoprotein and KG-CAM protein by mAb F84.1 and l1-59 to identify the N-terminal amino acid sequence is basically the same expression in different tissues with a substance were found in the goldfish in the DM-GRASP congeners called neurolin, expressed in the development of retinal ganglion cells. 1997 Uehida serum from rat neural cell lines XKM monoclonal antibody F84.1 identify human bone marrow cells, found that may cross-react with the corresponding antigen, they name huHCA.